Sirolimus Test

Sirolimus Blood Test

Sirolimus, also known as rapamycin, is a drug that suppresses the immune system in individuals with a kidney transplant. This medicine is combined with other medicines to prevent the rejection of transplanted kidneys. Hence, the Sirolimus test analyses its levels in the blood.

Usually, an individual’s immune system identifies a transplanted organ as foreign material and begins to exhibit coping strategies. Sirolimus reduces this response and prevents organ rejection by inhibiting the production and activation of white blood cells known as T- lymphocytes. It also obstructs the production of antibodies. 

You might want to see the use of the Sirolimus blood test !

The higher-than-normal levels may cause signs linked with toxicity, such as nausea, increased blood pressure, insomnia, fever, headache, excessive bleeding, and chest pain.

The low Sirolimus level test may signify that more drug quantity is required for achieving a therapeutic dose. However, low levels may result in the rejection of the transplanted organ. The clinician will titrate the dose accordingly. 

Signs and symptoms

Call for immediate action for healthcare providers are

• Fast heart rate
• Unusual bleeding
• Swollen, cracked, red, and scaly skin
• Difficulty in swallowing
• Pale skin.

Major complications or side effects are: 

• Slow healing
• Infections
• Increased lipid levels
• Weight gain
• Fever
• Sensitivity to Sunlight

Test Details

Interpretation of Sirolimus blood test result

A level higher than the established therapeutic range might cause signs linked with toxicity. The low levels may result in the rejection of the transplanted organ. The specialist may titrate the dose given to the patient. If an individual takes other medicines or immunosuppressants, you must discuss it with the transplant team and doctor to avoid potential interactions between various medications.

Important things to consider for the test

Food or drugs that accelerate or inhibit sirolimus may influence blood levels. You must discuss with the doctor about supplements or medications taken. The medicines such as clarithromycin, antifungals, erythromycin, protease inhibitors, carbamazepine, and rifampicin, among others. 

The administration of Sirolimus must be strictly done under the doctor's supervision. Also, avoid taking it with meals. The females must not get pregnant while taking it. Moreover, it must not be used with medicines that weaken immunity and enhance the risk of infection. 

Book the Sirolimus test from Redcliffe Labs.

You can schedule the test from Redcliffe Labs as the sirolimus test price easily comes into your budget. Also, you get the benefit of the availability of accurate reports online. The labs have state-of-the-art testing facilities and machinery to conduct the Sirolimus test. 

Hence, the Sirolimus test detects the sirolimus levels in the blood. Usually, the blood sample is collected 12 hours before the last dose of medicines and before the next dose. This test must be strictly taken under the supervision of the doctor. The specialist asks to go for a test for the evaluation of blood cell count and organ function.