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Clinical Case Studies
Individual diagnoses where a laboratory result changed the direction of care — written up by the pathologist or clinician who verified the report.
We publish these because a reference range on its own rarely settles a case. What settles it is the reflex test somebody ordered, the interference somebody spotted, or the smear somebody looked at again. Every case is fully de-identified and carries documented patient consent.
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When Severe Anemia Revealed Sickle Cell Disease During Pregnancy
A 27-year-old pregnant woman with no significant previous medical history presented with fever, shortness of breath, and difficulty standing . She appeared very pale and had jaundice , while ultrasound revealed hepatosplenomegaly , or enlargement of the liver and spleen. Her CBC showed severe anemia , with hemoglobin reported at 3.7 g/dL and a very low RBC count, along with an elevated WBC count. The peripheral smear showed target cells, nucleated red blood cells, and a few doubtful sickle-shaped cells , prompting further investigation. A sickling test was positive , and confirmatory testing through HPLC/haemoglobin electrophoresis confirmed sickle cell disease . As Dr. Yogitha Namasani, Labs Head at Redcliffe Labs, Hyderabad , explains, sickle cell disease is an inherited genetic condition in which abnormal hemoglobin can make red blood cells rigid and sickle-shaped, potentially leading to serious complications.
Case Overview A 27-year-old pregnant woman with no significant previous medical history presented with fever, shortness of breath, and difficulty standing . She appeared very pale and had jaundice , while ultrasound…
Dr. Yogitha NamasaniPublished October 2026Read moreHow a Simple Stool Test Identified the Cause of a Child's Diarrhea
A 1.5-year-old boy was brought in with watery diarrhea alternating with grey stools for 2–3 days. He also had vomiting, crampy abdominal pain, fatigue, poor food intake, loss of appetite, and fever . Several conditions could have caused these symptoms, including bacterial, viral, or parasitic infections . In a child of this age, lactose intolerance could also present with similar symptoms. A stool sample was examined using direct microscopy and concentration methods to identify the underlying cause. Microscopy revealed characteristic Giardia cysts , confirming acute giardiasis . The finding was communicated to the treating doctors without delay, helping the child receive appropriate treatment and reduce immediate risk.
Case Overview A 1.5-year-old boy was brought in with watery diarrhea alternating with grey stools for 2–3 days. He also had vomiting, crampy abdominal pain, fatigue, poor food intake, loss of appetite, and fever .…
Dr. Mayanka Lodha SethPublished October 2026Read moreMost recent
When Severe Anemia Revealed Sickle Cell Disease During Pregnancy
Case Overview A 27-year-old pregnant woman with no significant previous medical history presented with fever, shortness of breath, and difficulty standing . She appeared very pale and had jaundice , while ultrasound…
Dr. Yogitha Namasani · 2026
October 2026How a Simple Stool Test Identified the Cause of a Child's Diarrhea
Case Overview A 1.5-year-old boy was brought in with watery diarrhea alternating with grey stools for 2–3 days. He also had vomiting, crampy abdominal pain, fatigue, poor food intake, loss of appetite, and fever .…
Dr. Mayanka Lodha Seth · 2026
October 2026When a "Viral Fever" Turned Out to Be Malaria
Case Overview A 43-year-old man with no significant medical history was admitted to a hospital in Mumbai with fever, chills, fatigue, breathlessness, and significant loss of appetite . The symptoms initially seemed…
Dr. Sonal Gupta · 2026
October 2026When TB Testing Revealed More Than Expected
Case Overview A 48-year-old woman presented with symptoms including fatigue, nausea, night sweats, fever, and weight loss, prompting further evaluation for tuberculosis (TB). Her sample tested positive for Mycobacterium…
Dr. Amit Singh · 2026