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Diagnostic expertise in practice

Clinical Case Studies

Individual diagnoses where a laboratory result changed the direction of care — written up by the pathologist or clinician who verified the report.

We publish these because a reference range on its own rarely settles a case. What settles it is the reflex test somebody ordered, the interference somebody spotted, or the smear somebody looked at again. Every case is fully de-identified and carries documented patient consent.

12Cases published
9Specialities covered
ConsentedEvery case de-identified before release

Featured

When a "Viral Fever" Turned Out to Be Malaria

A 43-year-old man with no significant medical history was admitted to a hospital in Mumbai with fever, chills, fatigue, breathlessness, and significant loss of appetite . The symptoms initially seemed consistent with viral fever . However, considering the monsoon season and the increasing incidence of dengue and malaria in Mumbai, the doctors decided to investigate further. His blood reports revealed low hemoglobin, low total leukocyte count, significantly low platelet count, and elevated ESR , prompting the laboratory team to consider malaria. Further examination through thick and thin blood smears detected Plasmodium falciparum , confirming falciparum malaria. The finding was communicated to the treating doctors without delay, and the patient's treatment was changed to antimalarial therapy . With timely diagnosis and appropriate treatment, the patient recovered within two weeks , highlighting how identifying the true cause of fever can make a significant difference in the course of treatment.

Case Overview A 43-year-old man with no significant medical history was admitted to a hospital in Mumbai with fever, chills, fatigue, breathlessness, and significant loss of appetite . The symptoms initially seemed…

Dr. Sonal GuptaPublished October 2026Read more

When TB Testing Revealed More Than Expected

A 48-year-old woman presented with symptoms including fatigue, nausea, night sweats, fever, and weight loss, prompting further evaluation for tuberculosis (TB). Her sample tested positive for Mycobacterium tuberculosis (MTB), confirming the presence of TB. However, detecting TB was only the first step. It was also important to understand whether the bacteria were resistant to the medicines being considered for treatment. Testing showed that the bacteria were sensitive to rifampicin but resistant to isoniazid. This indicated isoniazid-resistant, rifampicin-susceptible TB, also known as isoniazid mono-resistant TB. The case, discussed by Dr. Amit Singh, Consultant Microbiologist at Redcliffe Labs, highlights why identifying the specific drug-resistance pattern matters when understanding an unexpected treatment outcome.

Case Overview A 48-year-old woman presented with symptoms including fatigue, nausea, night sweats, fever, and weight loss, prompting further evaluation for tuberculosis (TB). Her sample tested positive for Mycobacterium…

Dr. Amit SinghPublished October 2026Read more