Test Details

JAK2 V617F Mutation Detection Test - Price, Purpose, Results

570017750
67% Off
5130 With vip  VIP

The testing detects myeloproliferative neoplasm (MPN) causes polycythemia, myelofibrosis and thrombocythemia.

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Includes1 Parameter
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Reports in (T&C)7 days
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Sample Required

Bone Marrow Fluids, Blood

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FastingNot Required

  You will Save 12050 on this Test

Additional Instructions

Documents Required for JAK2 V617F Mutation Detection Test

Duly Filled TRF
This form will be provided by our sample collection expert and must be filled by you.
It includes your name, age, contact details, and some basic health information.


• Doctor’s Prescription
A doctor’s note recommending the WGS test is required.
An OPD card is also acceptable.


• Health and Family History (If available)
Details about your health conditions and any similar health issues in your family.
This helps us understand if the condition may be genetic or environmental.


• Old Medical Reports (If available)
You can share any past medical records such as:
MRI scans, ultrasound reports, blood tests, ECG, TMT, etc.

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JAK2 V617F Mutation Detection (1)

  • JAK2 V617F Mutation Detection

Introduction to JAK2 V617F Mutation Detection Test

The JAK2 V617F mutation detection test helps diagnose bone marrow disorders known as myeloproliferative neoplasms (MPNs). In these conditions, the bone marrow produces too many blood cells. The test plays a crucial role in diagnosing and distinguishing between various MPNs. 

The JAK2 (Janus Kinase 2) V617F mutation is easily detected by real-time PCR in patients with chronic myeloproliferative disorders (CMPDs). The CMPDs are classified as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Further, MPN has been associated with 98% mutation in patients with PV, ET, and PMF with 50% showing JAK2 mutation. 

12 Common conditions that may prompt for a JAK2 V617F: 

  1. Irritable bowel disease (IBD, including Crohn’s disease
  2. Weakness and fatigue
  3. Shortness of breath
  4. Loss of appetite
  5. Night sweats
  6. Bone and joint pain 
  7. Enlarged spleen 
  8. Unexplained weight loss
  9. Kidney stones
  10. Gout 
  11. Itchiness 
  12. Numbness

A healthcare professional may suggest a need for a JAK2 V617F when you have a family history of the MPNs disorder, symptoms of MPNs, or you may have a bone marrow disorder, including PV, ET, and PMF. 

Healthy India Ki Trusted Lab-Redcliffe Labs offers a variety of routine and specialized tests for all age groups. The test involves a blood draw or bone marrow fluids. Book a  JAK2 V617F Mutation Detection Test online with a home sample collection, allowing you to get tested from the comfort of your home. 

We understand how precious your time is, and completing the test on time may be impossible. Our phlebotomist will visit your home with a sample collection kit and follow all guidelines to ensure smooth and efficient diagnostic services within a time frame. 

Test Details:

Also Known As JAK2 mutation analysis, JAK2 gene mutation test, JAK2 V617F PCR test, and JAK2 mutation detection by DNA sequencing. 
Purpose The testing detects myeloproliferative neoplasm (MPN) causes polycythemia, myelofibrosis, and thrombocythemia. 
Preparation Do not drink or smoke before the test. 
Sample Blood marrow fluids, blood. 
Test available for  Age Group: 5+ years
Fasting No fasting required
Get Reports Within 6 days
Actual Price INR 17, 750
Cost Offered INR 5700 

What is the purpose of a JAK2 V617F Mutation Detection Test?

A healthcare provider usually orders a JAK2 V617 F mutation detection test to support the diagnosis and classification of myeloproliferative neoplasms (MPNs), including: 

  • Polycythemia Vera (PV)

This type of blood cancer causes your bone marrow to make too many red blood cells (RBCs). Too many RBCs can thicken your blood and slow its flow, which may result in several serious problems, such as blood clots. 

The average life expectancy of a person with PV is 20 years. 

  • Essential Thrombocythemia (ET)

Essential thrombocythemia (ET) is a condition in which the body makes too many blood cells called platelet-producing cells (megakaryocytes) in the bone marrow. This condition may cause problems such as heart attacks and/or strokes. Although the exact cause of ET is unknown, experts believe that it may be a change in the JAK2 gene. 

The average life expectancy of a person with ET is also 20 years. 

  • Primary Myelofibrosis (PMF)

Alternatively known as chronic idiopathic myelofibrosis, Primary myeloproliferative (PMF) is a condition in which there are too many platelet-producing cells, causing extensive scarring in the bone marrow. 

The average life expectancy of a person with PMV is 14 years. 

Other Reasons When a Doctor May Suggest a Test: 

Apart from the reasons above, the JAK2 V617F Mutation Detection Test may also be ordered: 

  • As a follow-up Test, The JAK2 V617F is typically ordered if your hemoglobin, hematocrit, red blood cells, and/or platelet count significantly increases. 
  • Symptoms suggestive of MPNs: The test may also be suggested when your healthcare professional suspects that you may have an MPNs, especially, polycythemia vera (PV), essential thrombocytopenia (ET), or primary myelofibrosis (PMF). 
  • Certain types of cancer: Although rare, the JAK2 mutation is also found in people with chronic myelomonocytic leukemia (CMML), acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and chronic myeloid leukemia (CML). 

Common symptoms include a blood clot in the vein, bleeding, headache, vision problems, and an enlarged spleen. 

If your doctor has suggested a JAK2 V617F mutation analysis, you need not delay it. We are a call away to book a test with a home sample collection, ensuring 100% report correctness. Early detection is crucial to help a doctor diagnose the condition and suggest a personalized treatment plan to improve health outcomes. 

What are the benefits of the JAK2 V617F Mutation Detection Test?

A JAK2 V617F test may be ordered when your doctor suspects you have a myeloproliferative neoplasm (MPN). The need for the test arises when common routine blood tests such as complete blood count (CBC) reveal abnormal results linked to MPNs. 

The test may be advantageous for several reasons, such as: 

  • Early diagnosis: The primary benefit of a JAK2 V617F mutation analysis test is to help in the early detection of myeloproliferative neoplasm, allowing for timely intervention. However, a negative  JAK2 V617F result does not confirm the absence of an MPN.
  • Accurate disease classification: The test also distinguishes between different types of MPNs, especially the three main types: Polycythaemia vera (PV), Essential thrombocythaemia (ET), and Myelofibrosis (MF). This helps a doctor initiate the treatment plan. 
  • Treatment guidance: The test helps a doctor determine which MPN you have and evaluate its severity. It also guides him on the need for medications when the JAK2 V617F mutation test is positive. 
  • Prognostic Value: The JAK2 V617F test assists in predicting disease progression and monitoring response to therapy. 
  • Distinguish from secondary causes: Besides all these reasons, the test helps rule out reasons for elevated blood cell counts, such as hypoxia or infections. 

What is the preparation for the test?

Preparing for the JAK2 V617F mutation detection test is simple. The test doesn’t require fasting, so you can consume your meals. Staying hydrated is also essential, as it helps keep more fluid in your veins, making a blood draw easier. 

If you take supplements or any medications, inform your healthcare provider about them before the test. Their ingredients can interfere with the test results and may not produce results accurately. 

Additionally, strenuous exercise before the test may cause hormone fluctuations, which you must be aware of. 

In case of any other doubt regarding the preparation for the JAK2 V617F test, ask your healthcare provider and get the most appropriate guidance. 

Procedure for the JAK2 V617F test 

Like preparation, the test’s procedure is also simple. It is performed primarily using a blood sample, but bone marrow fluids may also be used. Let’s learn about them in detail. 

  • Blood Sample

A healthcare professional or phlebotomist will visit your home with a blood collection kit, including a needle holder, evacuated collection tubes, a gauze pad, and a tourniquet band. 

First, he will tie a tourniquet band around your arm, and search for a suitable vein in your arm. This is to avoid multiple puncture wounds. 

Then, he will insert a needle into a vein in your arm and collect blood. 

Then, he will release the band and apply a cotton gauze to prevent infection or excessive bleeding. 

After that, he will transfer the collected blood into a vial or test tube and label it. 

The sample will undergo laboratory analysis to detect the JAK2 V617F test mutation in blood cell DNA. 

Note: Inform a phlebotomist about your inhibitions regarding the blood test so that he can be more careful. Although rare, seek medical advice immediately in case of nonstop bleeding, bruise, or infection. 

  • Bone Marrow Fluid test

A doctor can only suggest a bone marrow fluid test to confirm the diagnosis if a blood test is inconclusive. Bone marrow testing is needed to assess the severity and progression of polycythemia vera (PV), essential thrombocytopenia (ET), and primary myelofibrosis (PMF) 

During this test, the skin and underlying tissues are first numbed using anesthesia to minimize discomfort. 

Then, a syringe is used to withdraw the liquid from the hip bone. 

Finally, the collected sample is sent to the laboratory for DNA analysis. 

What does the test result indicate?

The JAK V617F mutation detection test may indicate positive or negative results: 

  • Negative (normal) Result

This means that no JAK2 V617 F mutation has been detected. No presence of MPN is detected, or an MPN is due to a different genetic mutation. 

  • Positive Result

A positive test result indicates the presence of the JAK2 V617F mutation. A positive JAK2 mutation test suggests a higher likelihood of polycythemia vera (PV), essential thrombocytopenia (ET), or primary myelofibrosis. 

Additionally, your healthcare provider may suggest additional testing such as a bone marrow biopsy, and check for other signs for confirmation. 

  • Other Variants

Sometimes, a standard V617 F test fails to reveal JAK2 exon mutations linked to polycythemia vera, which is possible through this test. 

Note: More than 95% of individuals with PV and 50-60% with ET and PMF have a JAK 2 mutation. Consult your physician to understand the meaning of your specific test results and help your practitioner suggest a treatment plan to manage the condition effectively. 

JAK2 V617F Test Price - Redcliffe Labs! 

Yes, with Redcliffe Labs, you can now book a JAK2 V617 F Mutation Detection test at INR 5700 only, making it affordable for all. The Janus Kinase gene 2, or JAK2 for short, looks for mutations that are associated with bone marrow disorders caused by the production of too many red blood cells. 

Hence, if suggested, call us at 898 898 8787 or follow the steps below to book a test online with a home sample collection. The reports are typically available in 6 days. 

  1. Visit the official Redcliffe Labs website: https://redcliffelabs.com/.
  2. Browse or search for the specific test you need. 
  3. Add the test to the cart. 
  4. Complete the payment process online.

Note: You will receive confirmation through SMS and WhatsApp. 

JAK2 V617F Mutation Detection Test Cost in Different Cities

City Name Discounted Price
Delhi ₹5700
Noida ₹5700
Mumbai ₹5700
Bangalore ₹5700
Kolkata ₹5700
Pune ₹5700
Lucknow ₹5700
Ahmedabad ₹5700
Hyderabad ₹5700
Chennai ₹5700
Gurgaon ₹5700
Jaipur ₹5700
Faridabad ₹5700
Indore ₹5700
Patna ₹5700

Note: We also offer JAK2 V617F Mutation Detection Test PAN India. Please call the number 8988988787 to check the availability of our services in your area.

Conclusion

The JAK2 V617F Mutation Detection Test is a valuable tool used to diagnose and manage blood disorders, particularly myeloproliferative neoplasms. While positive results suggest a high probability of bone marrow disorders, and may create a need for further tests and clinical evaluations. 

If you have MPN-related symptoms or abnormal blood counts, consulting a hematologist for further evaluation is recommended. 

Frequently Asked Questions

What is the JAK2 V617F mutation?
The JAK2 V617F mutation refers to a genetic change in the JAK2 gene. It can result in abnormal blood cell production, commonly found in myeloproliferative neoplasms (MPNs) like polycythemia vera, essential thrombocythemia, and myelofibrosis.
    How is the JAK2 V617F mutation detected?
    The Janus Kinase 2 V617 F is detected through a blood test or, in some cases, a bone marrow fluid is used to analyze DNA.
      What are the symptoms of the JAK2 V617F mutation?
      Symptoms associated with a JAK 2 V617 F test may include dizziness, night sweats, enlarged spleen, fatigue, headaches, and blood clots.
        Is the JAK2 V617F mutation hereditary?
        No, the JAK2 V617F is not inherited, it is an acquired mutation, meaning it develops during your lifetime.
          Can the JAK2 V617F mutation be cured?
          There is no cure for JAK2 V617 F. A healthcare professional may suggest treatments like medications, blood thinners, and targeted therapies to help manage symptoms and prevent complications.

            Frequently Asked Questions

            What is the JAK2 V617F mutation?
            The JAK2 V617F mutation refers to a genetic change in the JAK2 gene. It can result in abnormal blood cell production, commonly found in myeloproliferative neoplasms (MPNs) like polycythemia vera, essential thrombocythemia, and myelofibrosis.
              How is the JAK2 V617F mutation detected?
              The Janus Kinase 2 V617 F is detected through a blood test or, in some cases, a bone marrow fluid is used to analyze DNA.
                What are the symptoms of the JAK2 V617F mutation?
                Symptoms associated with a JAK 2 V617 F test may include dizziness, night sweats, enlarged spleen, fatigue, headaches, and blood clots.
                  Is the JAK2 V617F mutation hereditary?
                  No, the JAK2 V617F is not inherited, it is an acquired mutation, meaning it develops during your lifetime.
                    Can the JAK2 V617F mutation be cured?
                    There is no cure for JAK2 V617 F. A healthcare professional may suggest treatments like medications, blood thinners, and targeted therapies to help manage symptoms and prevent complications.

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