HLA B27 Test - Price, Purpose, Preparation, Report, & More

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Introduction to the HLA B27 Test

The HLA B27 Test helps to determine the presence of the human leukocyte antigen B27 (HLA-B27) on the surface of cells. The tests also evaluate the risk of autoimmune disorders associated with the presence of HLA-B27. The autoimmune disorders occur when the immune system mistakenly attacks its own cells and tissues. The test helps diagnose health conditions like ankylosing spondylitis, reactive arthritis, and psoriatic arthritis.

If you are experiencing the symptoms of chronic pain in bones, stiffness, and inflammation in the body, then you must consult your doctor. On the basis of your symptoms, your doctor may recommend that you take the HLA B27 Test. Moreover, people who have a family history of autoimmune disorders are advised to undergo this test as a preventive measure. Choose Redcliffe Labs as your reliable diagnostic partner for your HLA B27 Test. With us, you will get the home sample collection and the reliability of getting accurate test reports. 

HLA B27 Test details in brief

What is the HLA B27 Test? 

HLA B27 test stands for the Human Leukocyte Antigen B27 test. B27 is an antigen on the surface of your white blood cells (WBCs), affecting your immune system. With a simple blood test, your doctor can determine the presence of HLA B27 proteins within your cells. 

The HLA B27 test price differs at every lab. Redcliffe Labs provides a competitive and affordable INR 2400 for the HLA B27 test. We believe quality diagnosis is the right of every Indian. Some of the common autoimmune disorders are Ankylosing spondylitis, Juvenile arthritis, and reactive arthritis.

Purpose of the HLA B27 Test

HLA-B27 is a specific protein found on the surface of white blood cells. The Human leukocyte antigens help the immune system distinguish between self cells, healthy cells of the body, and nonself cells, foreign invaders like bacteria, viruses, and cancer cells. People who have HLA-B27 cells are at high risk of autoimmune diseases such as ankylosing spondylitis (AS), juvenile rheumatoid arthritis (JRA), and reactive arthritis (of which one subset is Reiter syndrome). 

• Diagnose autoimmune diseases- The presence of HLA B27 is associated with autoimmune diseases like- 
1. Ankylosing spondylitis (AS)- causes chronic inflammation and affects the spine, neck, and chest.
2. Reactive arthritis (ReA)- is triggered by an infection and causes inflammation in joints, urethra, and eyes. 
3. Juvenile idiopathic arthritis (JIA)- is a type of arthritis that affects children under 16.
4. Anterior uveitis- causes inflammation in the eyes.
5. Behçet's disease- is an autoimmune disease that causes inflammation in the body.
6. Psoriatic arthritis- a type of arthritis associated with psoriasis, a skin condition.

• Assess disease risk- The HLA B27 Blood test assesses the risk of having autoimmune diseases in those who carry the HLA-B27 gene. 
• Monitor disease progression- The test monitors the HLA-B27 levels to identify disease activity and guide treatment decisions. 
• Differentiating between health conditions- The symptoms might overlap with various diseases. The HLA-B27 can help to distinguish between health issues and a more accurate diagnosis and appropriate treatment plan.

What does the HLA B27 Test detect?

The HLA-B27 test detects the presence of a human leukocyte antigen (HLA) called HLA-B27. The test identifies whether a person carries the HLA B27 gene variant. The presence of HLA B27 is related to an increased risk of developing certain autoimmune diseases that affect joints and the spine, such as ankylosing spondylitis and other forms of spondyloarthritis. Given its role in identifying potential autoimmune disorders, the HLA-B27 test is an important marker of comprehensive medical evaluations. Timely detection of HLA B27 can help healthcare professionals formulate effective treatment plans and improve overall patient outcomes.

What Is The HLA B27 Test Used For? 

A HLA-B27 test can be used for many reasons. Let’s look at them. 

• Confirm a suspected diagnosis of ankylosing spondylitis (AS), juvenile rheumatoid arthritis, or sometimes anterior uveitis. 
• Rule out an autoimmune disorder. 
• Evaluate signs and symptoms to understand your medical condition. 
• Locate asymptomatic signals in people with recurrent uveitis. 

What Does The HLA B27 Test Measure?

An HLA B27 test measures the absence or presence of an HLA B27 antigen, which easily rules out risks of autoimmune disorder. An HLA-B27 positive indicates the dangers linked with autoimmune disorders, while an HLA-B27 negative antigen shows the absence of this gene variant in WBCs. 

When and Why You Should Take The HLA B27 Test? 

The HLA B27 test measures the HLA B27 levels in your blood. The HLA B27 test price differs based on location, lab, equipment, and techniques. You should take the test: 

• To check the chances of autoimmune disorders 
• To determine the presence of HLA B27 on the surface of your cells. 

You should book the HLA B27 test when you experience: 

• Chronic joint pain 
• Stiffness and inflammation in your hips, necks, lower back, and chest
• Uveitis (painful inflammation of the eyes) 
• Male above 30 years. 

What Are The Causes of Autoimmune Disorder Linked with HLA-B27? 

The cause is usually unknown. However, research came with several points. They observed that people with reactive arthritis were associated with microbe infections such as Salmonella, Yersinia, Campylobacter, and Ureaplasma. 

Studies have found that HLA-B27 antigens and antigens on infected surfaces trigger the immune system, which causes an autoimmune disorder. 

What Other Tests Can Your Doctor Suggest Alongside the HLA B27 Test? 

The HLA B27 test can determine the risk of autoimmune disorder by measuring the HLA B27 or human leukocyte antigen B27 on the surface of your cells. For 100% confirmation, your doctor can suggest other tests, including: 

• C-reactive Protein Test 
• X-Rays 
• Erythrocyte Sedimentation Rate (ESR) 
• Rheumatoid Factor 
• Anti-CCP Antibody Test 

If they recommend the above tests, along with the HLA B27 test, book them from Redcliffe Labs. We are a leading diagnostic laboratory with 3600+ blood tests. You can book a test from our website or app. After booking the test, our phlebotomist will come to your home to collect the sample. We offer an affordable price with the shortest turnaround (TAT). 

Preparation for the HLA B27 Test

The test does not require any or minimal preparation. Follow the guidelines below to ensure accurate test results- 

• Consult your doctor before the test about any medications, allergies, or medical conditions, as these factors might affect your test results.
• Generally, the HLA B27 Blood test does not require fasting. However, consult once with your healthcare professional before taking the test.
• Avoid strenuous exercise for a few hours before the test.
• Avoid smoking and alcohol consumption to ensure the accuracy of your results.

The procedure of the HLA B27 Test

The HLA-B27 is a standard blood test that requires sample collection from the vein. The phlebotomist first ties a tourniquet to the arm area and cleans it with an antiseptic solution. After that, he will use a sterile needle to collect the blood sample from the vein of your arm. You might feel a little pinch and discomfort during the blood drawing process, but this will be gone in a few minutes. The process of sample collection will take only 2- 5 minutes. After sample collection, the Phlebotomist will put a cotton gauze or bandage to stop bleeding. The sample will be sent to the laboratory for further analysis. 

What are the risks of the HLA B27 test?

The HLA B27 test is a simple blood test. You might have little discomfort or pain during the blood drawing procedure, but that is completely normal. The HLA B27 Blood test has no or minimal risks like other blood tests-

• Dizziness 
• Fainting
• Excessive bleeding
• Risk of infection at the puncture site
• Hematoma, blood clot under the skin
• Multiple punctures during blood sample collection

HLA B27 Test Result Interpretation

Is the HLA B27 Test For Everyone? 

The HLA B27 test measures HLA B27 antigen levels in your blood and locates the risk of autoimmune diseases. The test is not a routine checkup, so not everyone needs it. Nonetheless, a doctor can recommend performing the test on people above 5 years after detecting any signs and symptoms. 

People with positive sides, symptoms, family history of autoimmune disorder, or any other medical history should take the HLA B27 Test. The test can predict whether you will develop an autoimmune disease. 

Is There Any Treatment For Abnormal HLA-B27 Antigen in the Cells?

Yes, there are treatments for curing the HLA B27 antigen. Your doctor is the best person to guide you through the treatment. The ultimate goal of treatment is to relieve pain, stiffness, or inflammation and prevent complications. Your doctor can recommend certain medications, surgery, and therapy for treating HLA B27. 

Medications such as nonsteroidal anti-inflammatory drugs are most commonly used as the treatment option. These medications can provide relief from pain, stiffness, and inflammation. However, excessive consumption can cause gastrointestinal bleeding. Always consult your doctor before taking any medications.

To treat HLA B27, your doctor can recommend physical therapy, as therapies are not always limited to mental aspects. Physical therapy provides pain relief and improves strength and flexibility. They might suggest some good exercises, like stretching and strengthening exercises. Also, get proper sleep, and maintain body posture while sitting and walking to see more effective results. 

People with ankylosing spondylitis don’t need surgery. A doctor may suggest surgery in case of severe inflammation or severe damage to the hip joint requiring replacement. 

What do the HLA B27 Test reports indicate?

The test reports will be available within 60 hours of sample collection. It is important to consult your reports with your doctor for comprehensive assessment and to determine the next steps in your care. The interpretation of reports shows- 

• Positive- The positive results indicate a high risk of autoimmune disease. The presence of HLA-B27 increases the risk of developing autoimmune and inflammatory diseases like- Ankylosing spondylitis, Reactive arthritis, Juvenile idiopathic arthritis, Anterior uveitis, Behçet's disease, and Psoriatic arthritis.
• Negative- The negative results mean that the HLA B27 antigen is not present in your blood. This significantly reduces your risk of developing the diseases mentioned above.

What if the HLA B27 Test reports are positive?

The positive HLA B27 test indicates the presence of HLA-B27 antigen in the blood. This increases the risk of developing certain autoimmune diseases. If your HLA B27 Blood test reports are positive, then consult with your doctor and get a thorough physical examination. On the basis of your symptoms and disease progression, your doctor may recommend treatment options. The treatment options may include some medications to control inflammation and pain, physical therapy, and lifestyle changes. Early diagnosis and treatment can help to improve health conditions and manage symptoms. 

What are the common symptoms related to abnormal HLA B27 Test levels?

The abnormal level of HLA B27 may cause various symptoms. These are some of the HLA B27 symptoms:-

• Back pain and stiffness
• Joint pain and swelling
• Enthesitis
• Less movement 
• Uveitis, Inflammation in the eyes, causes redness and blurred vision
• Fatigue
• Skin lesions
• Fever
• Digestive issues

When do the doctors recommend the HLA B27 test?

There are many circumstances when doctors recommend the HLA B27 test, including-

• Unexplained symptoms like chronic back pain, stiffness, and eye inflammation. 
• People who have a family history of HLA-B27-associated diseases are advised to take the HLA B27 test.
• People who are suffering from specific medical conditions like Uveitis, Acute anterior uveitis, and Psoriasis must take the HLA B27 blood test.

HLA B27 Test price at Redcliffe Labs

The HLA B27 Test price is INR 2400 at Redcliffe Labs. Download the Redcliffe Labs App to book your test online. We ensure we provide you with the best diagnostic experience at affordable prices. With us, you don't need to go anywhere for the tests, our Phlebotomist will come to your home for sample collection. Our labs are NABL-accredited and ISO-certified, so you need not worry about the quality and accuracy of test results. Search "HLA B27 Test near me" and book your test today to assess your health conditions. 

Price of HLA B27 Test in Different Cities with Redcliffe Labs

Know What Your HLA B27 Test Reveals

The HLA B27 test determines if the human leukocyte antigen is present or absent. The HLA-B27 blood test diagnoses a potential autoimmune disorder. The test identifies autoimmune diseases like Ankylosing spondylitis (AS), reactive arthritis, and juvenile rheumatoid arthritis (JRA). If you observe symptoms like joint pain, stiffness, and inflammation in the eyes, always consult your doctor. 

If you find positive results, consult your healthcare providers to monitor and manage your health effectively. The test is essential for people as it helps in early detection, effective management, and improved outcomes for individuals at risk of autoimmune conditions associated with this antigen.

Get an HLA B27 blood test from Redcliffe Labs to identify the cause of symptoms and get treated early.