The liver is responsible for handling various metabolic functions in the body. Not only just, but the liver also detoxifies the blood and is responsible for processing different waste products in the hemoglobin.

To conduct all of these functions properly, the liver produces and secretes several types of enzymes for optimal regulation. SGOT or Serum glutamic oxaloacetic transaminase and SGPT or Serum glutamate pyruvate transaminase are two of the most common enzymes produced by the liver.

Your doctor will prescribe getting an SGPT & SGOT test to analyze your liver function and rule out possible complications.

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This article will explore more about these enzymes, the significance of the test, and the test results.

What is SGPT and SGOT?

SGPT and SGOT are two of the most common types of liver enzymes.

Besides the liver, SGOT is found in the kidney, muscles, heart and even the brain. On the contrary, SGPT is predominantly found in the liver only.

Elevated levels of either of the enzymes can result from:

  • SGOT levels can rise during liver complications, heart attacks or muscle injuries.
  • SGPT levels can rise during liver diseases and damage to the tissues in the liver.

The SGPT levels are more inclined towards determining liver diseases and damage due to its elevated levels.

What are the symptoms of elevated SGPT and SGOT levels?

If you see a doctor with the following symptoms, they might suggest undergoing the SGPT & SGOT tests. Some common danger level of SGPT and SGOT symptoms include:

  • Constant feelings of fatigue and tiredness
  • Vomiting and nausea
  • Swelling in the leg
  • Shortness of breath
  • Jaundice
  • Bruising quickly

Experiencing these symptoms is a warning sign that you need immediate medical intervention. If the test reports come back with high SGOT and SGPT levels, your doctor will move ahead with further testing or proceed with the treatment.

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What are normal levels of AST (SGOT) and ALT (SGPT)?

The normal ranges of SGOT and SGPT are standard. However, the range can slightly vary, depending on the testing method in the laboratory.

  • Normal SGOT levels – 5 to 40 units per liter of serum
  • Normal SGPT levels – 7 to 56 units per liter of serum

If the blood test reports are drastically different than the normal range, it can signify potent complications in the body, especially with liver diseases and disorders.

What do Elevated SGPT and SGOT levels Indicate?

Since SGPT and SGOT are quintessential enzymes produced in the liver, it isn’t surprising that altered levels of these enzymes indicate signs of liver damage.

The high levels are often indicative of several underlying complications in the body. Elevated levels of these enzymes aren’t SOLELY related to liver damage or disease. It can mean other complications too.

In some cases, the danger level of SGPT and SGOT indicate muscle damage or muscle diseases. The results from the blood test reports of SGPT and SGOT cannot accurately determine the degree of liver disease or damage in the patient.

Are SGPT and SGOT Indicative of Liver Disease only?

As we mentioned, that isn’t the case at all. Lower or elevated SGPT and SGOT enzymes aren’t just tied with liver disease or liver function.

Sometimes, patients with elevated levels of these two enzymes have an optimal liver function. It can be the complete opposite as well.

How can I prepare for the SGPT/SGOT Blood test?

The SGPT/SGOT blood tests are a part of the liver function test and are routine blood test that doesn’t require excessive prepping. The patients don’t have to fast or worry about the day when the blood is drawn.

However, for accurate results, we’d recommend discussing the medications you take. Since medications can alter the final reports, your doctor might advise getting the blood drawn before taking the medications.

The phlebotomist will collect the blood sample from the veins in your forearm after disinfecting the area. The collected sample is then sent for further testing to the laboratories.

Are there any risks associated with the SGPT/SGOT blood tests?

The SGPT/SGOT assessment in the body is done using a blood test. This means that the risks associated with these routine blood tests are very low and sometimes non-existent.

However, in very rare cases, some of the common risks might include:

  • Excessive bleeding at the puncture site
  • Hematoma or clotted blood underneath the skin
  • Feeling lightheaded
  • Infection

What do the Abnormal Test results Indicate?

Abnormal SGPT-SGOT levels in the bloodstream can be indicative of several complications, including:

  • Hepatitis
  • Liver cirrhosis
  • Liver tissue damage
  • Liver cancer
  • Tumor in the liver
  • Obstructed blood flow to the liver
  • Hemochromatosis or iron build-up in the bloodstream
  • Mononucleosis caused by Epstein-Barr virus
  • Pancreatitis

If you have lower SGPT-SGOT levels in the bloodstream, that indicates a healthy liver. Unlike other markers, a low level, in this case, doesn’t signify anything alarming.

What is the cost of the SGPT-SGOT Blood test in India?

The SGPT-SGOT blood test in India typically starts from INR 80 each. The price will vary depending on the city and the laboratory the test is done in.

Conclusion

SGPT and SGOT are key markers of liver function. If your doctor has prescribed these tests, it can indicate that they want to assess the state of your liver function along with other allied physiological functions. This routine blood test doesn’t come with any prominent risks or side effects. 

 

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Prekshi Garg is a young, dynamic, energetic, and meritorious professional biotechnologist. She is a merit rank holder in her post-graduation and a skilled bioinformatician with great zeal to do her best in neurosciences. She is currently working in the area of Neurotranscritomics dealing with neurodevelopmental and neurodegenerative disorders. She has presented many papers at different scientific forums and is awarded ‘Representing the Institution in Scientific Events’ citation by Amity University Uttar Pradesh and Top position in Student Assistantship Program held at Amity University in addition to awards won for oral presentations in different scientific deliberations. Prekshi has published a good number of papers and book chapters during the start of her academic career itself. Her tremendous skills and knowledge make her a good blend of biotechnology and bioinformatics.

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