The Hidden Hunger: Unveiling Vitamin Deficiencies in Diabetes

Medically Reviewed By
Dr. Mayanka Lodha Seth
Written By Komal Daryani
on Aug 4, 2025
Last Edit Made By Komal Daryani
on Aug 4, 2025

When your blood sugar is normal, you have effectively managed your diabetes by taking your prescribed medications on schedule and maintaining a healthy diet. However, what causes your hands or feet to tingle, feel tired, or have infections? In diabetic individuals, the hidden vitamin shortage is the true culprit, in addition to sugar.
More than 60% of people with diabetes have vitamin D deficiency, and over 30% have vitamin B12 deficiency, according to studies. Not only is a bad diet to blame for this mismatch, but diabetes, metabolism, certain medications, and poor nutrition also play a part. You will discover in this article the various vitamin deficiencies that lead to blood sugar rises in diabetic patients and how each of us can prevent this by taking some significant actions.
Reasons for vitamin deficiency in diabetic patients
There are several reasons that contribute to the causes of vitamin deficiencies in diabetic patients.
High Blood Sugar levels
The metabolic problems and excessive nutritional losses can cause either type 1 or type 2 diabetes. Long-term spikes in glucose levels cause an increase in urine output, which flushes away water-soluble vitamins, such as B1, B6, and B12. Chronic urination results in the depletion of several essential nutrients as the kidneys become overworked, which can impair immunity and lead to exhaustion.
Medications Interference
Due to their disruption of multiple parameters, diabetic drugs also affect the human body's general functions. Every diabetes patient is prescribed the common medication metformin. This medication reduces vitamin B12's absorption because it interferes with its calcium-dependent uptake. It can also occasionally affect vitamin B12, known as folate. Globally, up to 30% of people taking metformin are found to have a B12 deficiency, according to research. Metformin reduces intestinal motility and can lead to intestinal bacterial overgrowth.
Ill-balanced Diet
Although it provides a significant quantity of energy, a diet high in calories and processed foods lacks appropriate nutrients. Many people with diabetes follow restrictive diets that also contain a lot of carbohydrates. Unfortunately, these diets lack nutrient-dense, micronutrient-rich foods such as lean protein, green leafy vegetables, salads, and fruits. A study found that between 40 and 60 percent of people with type 2 diabetes suffer from multiple nutritional deficiencies.
Also Read: Role of Vitamins and Nutrients in Managing Weight Naturally
Metabolic and Inflammatory Effects
One of the main reasons people with diabetes experience chronic metabolic and inflammatory stress is vitamin deficiency. The type of diet you follow has a direct impact on it. Type 2 diabetes leads to inflammation and oxidative stress in the body due to elevated blood sugar levels and excessive body fat. Low vitamin D levels can cause the body's metabolic processes to slow down, which can ultimately erode the immune system.
Common Vitamin Deficiencies in Diabetes
Here are some vitamin deficiencies that are commonly seen in diabetic patients:
1. Vitamin D
The observable aspects that are influencing and exacerbating vitamin D deficiency in diabetes include insulin resistance, bone health, and an elevated risk of fracture. Vitamin D supplements can enhance insulin secretion and reduce insulin resistance. People with diabetes are at higher risk for nerve damage and kidney disease (nephropathy). Additionally, it contributes to the body's internal inflammation.
2. Vitamin B12
There are clear aspects that contribute to vitamin B12 deficiency in diabetes, including anemia and nerve function. Vitamin B12 deficiency can be triggered by metformin use and blood sugar fluctuations. Other drugs that affect stomach acid production, such as proton pump inhibitors and H2 blockers, can decrease the absorption of B12. Additionally, this slows down the body's metabolism, which can lead to poor glucose management and cardiovascular problems.
3. Vitamin C
People with type 2 diabetes experience a "renal leak" of vitamin C. It means that vitamin C deficiency is made worse by the kidneys excreting more vitamin C than is normal. Diabetes-related vitamin C deficiency is caused by elevated blood sugar levels that impede vitamin C absorption. Because of this deficiency, diabetic patients may have slower wound healing and higher levels of oxidative stress.
4. Magnesium
In diabetics, insulin resistance and poor glucose tolerance are comparatively associated with magnesium deficiency. Low magnesium levels can cause insulin resistance because they interfere with insulin's ability to bind to cell receptors and initiate the body's glucose metabolism. This insufficiency disrupts the metabolism of glucose, which in turn affects the synthesis of ATP (energy). In addition to these, many other vitamins, such as thiamine (B1), are also important. Vitamin A, vitamin E, and vitamin B6 also have an impact on individuals with diabetes.
Addressing Vitamin Deficiencies in Diabetes Management
Once diabetes is present, managing it in the long run is crucial. Accepting this fact and adapting a lifestyle accordingly is the right choice. Addressing diabetes management is itself an essential process, but it is not the only solution. Here are the ways to address various vitamin deficiencies:
- Dietary sources are more helpful and should be the first approach. Changing eating habits and inculcating a healthy diet are sustainable. Including green, leafy vegetables, whole grains, seasonal fruits, seeds, and nuts can help manage the deficiency over time.
- If someone has diabetes, they should have regular testing at intervals to check for vitamin B12 and vitamin D deficiencies.
- Whenever you think it is necessary to take supplements for vitamins D and B12, consult your doctor first and then take them. These supplements will provide the support to improve metabolic function, nerve health, and glycemic level control.
- Based on exposure to medications such as metformin, PPIs, and diuretics, it is the healthcare provider's responsibility to evaluate the need for medication.
- Lifestyle management that includes regular exercise, which improves insulin sensitivity and enhances nutrient metabolism, as well as sun exposure and effective weight management, is a crucial factor in addressing deficiencies of various vitamins.
Also Read: Different Types of Blood Sugar Tests: Check the List
Conclusion
Managing blood sugar levels requires a systematic approach, making it a significant responsibility. Being intimately familiar with your own body is one of the most challenging things you will ever have to do as an individual. When something is amiss within your body, you will always receive a signal. It takes more than just taking medicine to treat the many vitamin deficiencies associated with diabetes; this is not a sustainable treatment. Furthermore, it is crucial to maintain several key parameters, including a healthy diet, regular physical exercise, seven to eight hours of sleep each night, routine monitoring of vital signs, and taking supplements for specific vitamin deficiencies if necessary.
In addition to helping you control and regulate your diabetes, this also boosts immunity, supports bodily metabolism, and fortifies your nerves. Regular health checkups are essential for understanding what is happening with your body and identifying the risks you should be concerned about. To learn everything there is to know about your body with a single click, visit Redcliffe Labs.
FAQs
Q1: What are the most common vitamin deficiencies in diabetic patients?
Vitamin D is the most frequent deficiency, followed by magnesium, B12, and iron, among type 2 diabetics.
Q2: Which vitamin deficiency causes or worsens diabetes risk?
Vitamin D deficiency is linked to insulin resistance and impaired glucose metabolism, which may contribute to the development of type 2 diabetes.
Q3: Why is vitamin B12 deficiency common in people with diabetes?
A: Metformin therapy, used widely in diabetes, impairs B12 absorption, leading to a deficiency in nearly 29–30% of users.
Q4: What deficiency causes delayed healing or frequent infections in people with diabetes?
A: Vitamin C and antioxidant vitamins A and E are often low in diabetes, impairing immune function and wound healing and increasing oxidative stress.


