Sperm DNA Fragmentation Test - Price, Purpose, Procedure

Introduction to Sperm DNA Fragmentation test

DNA Fragmentation is the type of male fertility test that helps to measure the amount of damaged DNA in a sperm sample. DNA is considered damaged when the strands or chains are broken. All men have the same amount of sperm in their DNA. The damaged DNA may indicate difficulty in achieving and maintaining pregnancy. The test analyzes sperm count and motility. If you and your partner are facing infertility without a clear cause, this test DNA Fragmentation test can offer valuable insights. However, if you are experiencing fertility problems, consult your doctor. Choose Redcliffe Labs for a sperm DNA Fragmentation test to get accurate, timely results. 

Test details in brief

Purpose of the DNA Fragmentation Test

The primary purpose of the DNA fragmentation test is as follows-

• DNA damage reduces the chance that the sperm will fertilize an egg. It increases the risk of miscarriage if fertilization does occur. 
• The test helps to identify the unidentified cause of infertility.
• The test is recommended for couples who have experienced multiple miscarriages.
•  If a couple has undergone multiple rounds of IUI or IVF without success, sperm DNA fragmentation testing may help determine if DNA damage is a contributing factor.
• A condition in which the veins in the scrotum are enlarged. Varicoceles can contribute to sperm DNA damage. However, the test helps to identify the condition. Preparation for the Sperm DNA Fragmentation test

Preparation for the Sperm DNA test

Unlike other blood tests and fertility, the sperm DNA test requires no special preparation. Here are the general guidelines to follow before the test-

• Avoid ejaculation into lubricants- Lubricants may interfere with the test, so abstain from using them during semen collection.
• Discuss medications-  Let your doctor know if you are taking any medications, as it might impact sperm quality.
• Avoid stress- Stress may temporarily affect sperm parameters.

The procedure of the Sperm DNA Fragmentation test

The Sperm DNA Fragmentation test is a non-invasive test that doesn't involve blood sample collection.

Here is the complete procedure of the test- 

There are several methods for this analysis, including:

• SCSA (Sperm Chromatin Structure Assay)- A widely used method for measuring DNA integrity.
• TUNEL (Terminal deoxynucleotidyl Transferase dUTP Nick End Labeling)- Detects DNA breaks in sperm cells.
• COMET Assay (Single-Cell Gel Electrophoresis)- Another method to assess DNA damage.

What do the Sperm DNA Fragmentation test reports indicate?

The sperm DNA fragmentation helps to know your DNA fragmentation. However, the test results indicate the following recommendations-

• Excellent to Good (less than or equal to 15% DFI)
• Good to Fair (greater than 15% to less than 25% DFI)
• Fair to Poor (greater than or equal to 25% to less than 50% DFI)
• Very Poor (greater than or equal to 50% DFI)

Who should take the Sperm DNA Fragmentation test?

The Sperm DNA Fragmentation test isn't recommended for everyone. Here are the cases where a doctor might suggest this test:

• Unexplained fertility
• Failed fertility treatments
• Couples experiencing multiple miscarriages
• Men diagnosed with varicocele
• People having certain medical conditions 
• Exposure to toxins

What causes sperm DNA damage?

The sperm DNA test is caused by damage to the sperm's DNA by molecules called Reactive Oxygen Species (ROS). These are naturally produced by the mitochondria, the sperm's energy source, but can accumulate to harmful levels. This damage is often referred to as oxidative stress. Here are some major causes of Sperm DNA fragmentation- 

• Varicocele
• Infections
• Lifestyle factors like smoking 
• Genital tract inflammation
• Drugs, chemotherapy, and radiation therapy
• Cigarette smoking and Environmental toxins
• Infrequent Ejaculation
• Hormone factors

Other factors-

• Age
• Genetic predispositions
• Medical conditions
• Testicular overheating

Sperm DNA Fragmentation test price at Redcliffe Labs

The Sperm DNA Fragmentation test cost at Redcliffe Labs is INR 4900. Choose Redcliffe Labs to get tested in a timely and accurate manner. We ensure you 100% correct reports or money-back guarantee offers because of how important test results and reliability are. 

We understand the importance of timely tests, and we promise to provide you with the on-time test results online. Most importantly, our labs are NABL accredited and ISO certified, which means you don't need to care about the reliability of labs. Choose Redcliffe Labs to get the best diagnostic services from the comfort of your home. 

Sperm DNA Fragmentation Test Cost in Different Cities

Note: We also offer Sperm DNA Fragmentation Test PAN India. Please call on the number 8988988787 to check the availability of our services in your area.

How a Sperm DNA Fragmentation Test Can Help?

A sperm DNA fragmentation test is a fertility test done to assess the integrity of the genetic material carried by sperm. It measures the amount of damage to the DNA in a man's sperm. DNA is the genetic material that carries instructions for building and maintaining an organism, and healthy sperm needs undamaged DNA to fertilize an egg and create a healthy pregnancy successfully. 

Studies show higher DNA fragmentation (damage) in the sperm of infertile men, potentially hindering embryo development. Interestingly, even men with normal semen analysis can have significant DNA fragmentation. This highlights the need for a more comprehensive approach to male fertility assessment.

However, if you've been trying to get pregnant without success, a Sperm DNA Fragmentation test could help. The test can provide valuable information if you've been unable to conceive after a year with no clear cause; this test can offer insights. However, by understanding sperm DNA health, doctors can recommend appropriate treatment options to improve sperm quality and potentially increase your chances of a successful pregnancy. Are you considering a Sperm DNA Fragmentation Test? Consult your doctor to see if it's right for you.