Double Marker Test in Kolkata

Introduction to Double Marker Test in Kolkata

Understanding Double marker test for Pregnancy

The Double Marker Test is a prenatal screening test used to evaluate the risk of chromosomal abnormalities in the developing fetus. It measures specific biomarkers in the mother's blood, including "free beta-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A). Combined with ultrasound findings and maternal factors like age, these markers provide a comprehensive risk assessment for conditions such as Down Syndrome (trisomy 21), Edward Syndrome (Trisomy 18), and other chromosomal anomalies. If you are pregnant, your doctor may recommend the double marker test in the first trimester. You can take the Double marker test in Kolkata from Redcliffe Labs; the professionals here provide 100% report correctness guaranteed with on-time reports.

Double Marker Test in Kolkata Test Details:

Importance of the Double Marker Test

The Double Marker Test is crucial to detecting genetic disorders early.

This double marker test helps to make informed decisions about further diagnostic testing and pregnancy management. It is conducted during the first trimester (between 11 and 14 weeks) as part of combined first-trimester screening.

Feminine fetuses, on average, have 22 pairs of XX chromosomes, whereas male fetuses have 22 pairs of XY chromosomes. 

However, Trisomy occurs due to an additional set of chromosomes.

Down syndrome occurs due to having an extra copy of chromosome 21, also known as trisomy 21.

Another common chromosomal abnormality occurs due to an extra copy of either chromosome 18 (Edward Syndrome) or chromosome 13 (Patau Syndrome)

Purpose of the Double Marker Test

The first-trimester screening—double marker test and NT scan—isn't mandatory. That said, it is recommended if you're over 35 or if you have a high risk of chromosomal issues, such as a family history of certain conditions. 

It is important to remember that the result only tells if you have a high risk of trisomies. It does not determine whether your baby has any abnormalities.

• Women aged 35 or older, as the risk of chromosomal abnormalities increases with age.
• Pregnant women with a family history of genetic disorders.
• Pregnant women with abnormal ultrasound findings.

Why Take the Double Marker Test in Kolkata?

The Double Marker test offers early insights into fetal health and helps to ensure timely medical interventions or lifestyle adjustments. However, the double marker test is important in prenatal care for any expectant parent who wants to prioritize a healthy pregnancy.

Who Should Take the Double Marker Test?

The double Marker Test helps to evaluate the risk of genetic disorders in the fetus. Here's who should take the test-

• Pregnant women between 11 to 14 weeks
• Women who are at high risk of advanced maternal age.
• Those with a family history of genetic disorders.
• Women with previous pregnancies that had chromosomal abnormalities.
• Women who had risk factors for chromosomal disorders.

What does the Double Marker test detect?

The Double Marker Test is recommended during the first trimester of pregnancy to monitor and evaluate the risk of chromosomal abnormalities. 

The test detects Down syndrome and Edward's syndrome (Trisomy 18) by measuring the levels of two key substances in the mother's blood:

2. PAPP-A (Pregnancy-Associated Plasma Protein A): The placenta produces this protein. Low levels of PAPP-A in the mother's blood can indicate a higher risk of genetic disorders, including Down syndrome and Edwards syndrome.
3. Free β-hCG (Human Chorionic Gonadotropin): The placenta also produces this hormone. High levels of free β-hCG can be associated with a high risk of Down syndrome, while low levels may indicate a higher risk for Edwards syndrome.

What preparation is required for the Double Marker test?

You don't require any special preparation before the Double Marker test. Here is what you must keep in mind before taking the test-

Remember, the test is done between the 11 to 14 weeks of the first trimester.

• You don't require fasting before the test. You can eat as usual. 
• If you take any medications or supplements, let your doctor know. Some medications may affect your test results. 

Always ensure that the double Marker test is accurate and provides information for your healthcare provider to assess the risk of chromosomal abnormalities. 

Procedure for the Double Marker Test

Unlike other blood tests, the Double Marker test is simple. Hence, the procedure will be the same. 

• The test is done between 9 to 13 weeks of pregnancy.
• Here is the step-by-step process for the Double Marker test. 
• The phlebotomist will ask to fold the sleeves and then clean the nerves with an antiseptic solution to reduce the chances of infection.
• He will tie a tourniquet around the arm and find the nerve to collect the blood sample. 
• After finding the right nerve, he collected the blood sample using a syringe or needle. 
• Once the sample is collected, he will tie a cotton gauze or bandage to stop the blood flow.
• During the sample collection, you might feel a little pinch, but this will eventually become normal. You can resume your daily activities after blood sample collection. 

What do the Double Marker Test reports indicate?

During the first trimester, the Double Marker test results provide risk ratios for chromosomal abnormalities such as Down syndrome (trisomy 21) and Edward's syndrome (trisomy 18). 

The test detects Beta hCG and PAPP-A. Beta hCG is 25,700-288,000 IU/ml for every age, while PAPP-A is 1 MoM. 

The test is prepared based on two factors-

1. PAPP-A (Pregnancy-Associated Plasma Protein A): A protein the placenta produces. Low levels of PAPP-A may indicate an increased risk of chromosomal abnormalities, particularly Down syndrome.
2. β-hCG (Human Chorionic Gonadotropin): A hormone produced during pregnancy. High levels of β-hCG can be associated with a higher risk of Down syndrome.

If double marker tests are abnormal, your doctor may recommend further diagnostic tests, such as NIPT (Non-Invasive Prenatal Testing), amniocentesis, or chorionic villus sampling (CVS), which may be recommended for confirmation.

You must always consult your reports with your doctor to understand your results. Your doctor will assess various factors, including your medical history, age, and the results of other tests or ultrasounds, to provide a clear interpretation.

What if the Double marker test reports are positive?

If your double marker test result shows abnormal values, it means you are at high risk of chromosomal disorders, including Down syndrome (trisomy 21) or Edward's syndrome (trisomy 18). Here is what you should do next-

Further Diagnostic Testing- A positive result from the Double Marker Test leads to recommendations for further diagnostic testing to confirm or rule out chromosomal abnormalities. These tests may include:

• Non-Invasive Prenatal Testing (NIPT): A blood test that examines fetal DNA to assess the risk of chromosomal conditions like Down syndrome without the risks associated with invasive tests.
• Amniocentesis: In this procedure, a small sample of amniotic fluid is taken from the uterus to analyze the chromosomes of the fetus. 
• Chorionic Villus Sampling (CVS): During CVS, a small sample of placental tissue is taken for genetic analysis. 
• Ultrasound Evaluation: Your doctor may recommend an ultrasound scan to assess the nuchal translucency. This measurement can provide additional information about the risk of Down syndrome and other chromosomal conditions.

What is the Cost of a Double Marker Test in Kolkata?

The Double Marker Test price at Redcliffe Labs ranges from Rs 2149 - Rs 2400. You can book your test using our Android app, Redcliffe Labs, or by calling our agents. 

We are available in 220+ cities across India through our wide network of 80+ owned advanced labs powered by 2000+ collection centers and home collection services. Our labs follow the highest quality standards. The resulting process is followed by 50+ internal & external quality control checks regularly. The professional uses fully automated machines with the latest technology. Also, we are trusted by more than 50000 doctors across India. We also provide value benefits worth INR 999/- with every test, including personalized diet plans, health progress reports, and free report consultation. What else do you need? Just call us and book your test today!

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What’s The Ideal Time To Perform The Double Marker Test? 

The Double Marker test is ideal during the first trimester of pregnancy, between 11 to 14 weeks of gestation. Here is why- 

• Optimal Window for Measurement—The test accurately measures specific markers in your blood (PAPP-A and free β-hCG) during 11 to 14 weeks. During this period, the levels of these hormones in the blood can provide reliable information about the risk of chromosomal disorders such as Down syndrome (trisomy 21) and Edwards syndrome (trisomy 18).
• Nuchal Translucency (NT) Ultrasound—The Double Marker Test is often combined with an ultrasound scan to measure the nuchal translucency (NT), the fluid-filled space at the back of the fetus's neck. 

The NT measurement can provide additional data for a more accurate risk assessment of chromosomal abnormalities. 

If your doctor has recommended the Double Marker Test, taking it for 11 to 14 weeks is best. 

Tips to Avoid Abnormalities During Pregnancy

To ensure a healthy pregnancy and reduce the risk, follow the tips below during pregnancy. 

• Get Early and Regular Prenatal Care—Early care helps monitor the health of both mother and baby. Get regular health checkups recommended by your doctor to avoid complications. Regular health checkups help catch issues early, such as gestational diabetes, high blood pressure, or potential genetic conditions.
• Taking Prenatal Vitamins—Prenatal vitamins, such as folic acid, are crucial for fetal development. Folic acid helps lower the risk of neural tube defects (like spina bifida) and supports brain and spinal cord development.
• Maintain a Healthy Diet—A balanced diet rich in fruits, whole grains, lean proteins, vegetables, and healthy fats supports both maternal and fetal health. 
• Avoid alcohol and tobacco- Do not take alcohol and avoid smoking, as usage of these items may cause birth defects, preterm birth, and developmental issues.
• Manage health conditions- If you have health complications such as high blood pressure, diabetes, and thyroid disorders, then start your medications early to avoid any abnormalities. 
• Stay Physically Active—Maintain a healthy and active routine, including daily exercise, low stress, and maintaining a healthy weight. 
• Protect yourself from pollutants. Exposure to certain chemicals, pollutants, or radiation can elevate the risk of birth defects or developmental issues.
• Don't take stress- Stress can negatively affect both mother and baby, leading to complications like preterm birth or low birth weight.
• Get adequate sleep- Getting enough rest is important for your body’s recovery and for supporting fetal development.

Why Choose Redcliffe Labs?

You should take the Double Marker test in Kolkata from Redcliffe Labs because-

• We provide 100% report correctness guaranteed and help you understand your baby's health risks early.
• The test is performed using advanced technology by highly qualified professionals.
• Convenient and timely reports 
• Affordable prices and great discounts and offers
• Accessible to PAN India