Factor V Leiden Mutation Test - Price, Purpose, Procedure

Table of Content

Introduction to Factor V Leiden Mutation Test 

Genetics plays a crucial role in maintaining a healthy body. Any inherited gene may cause defects. DNA, chromosomes, mutations, and mitochondrial DNA contribute to genetics, which regulate body type, appearance, disease, mental ability, and protein production. Variations in genetics lead to blood clotting, such as prothrombin thrombophilia and factor V Leiden thrombophilia. Factor V Leiden Mutation test helps detect and diagnose abnormal mutation of Factor V, which may cause disease or infection. 

Redcliffe Lab is India’s leading diagnostic lab, and it believes that quality diagnostics is the right of every individual. We have over 3600 tests, making them affordable and accessible with a low-cost home sample collection service. The factor V Leiden Mutation test price is INR 5900, which you can book from our website or mobile application. 

Test Details in Brief 

What is the Factor V Leiden Mutation Test? 

The Factor V Leiden mutation test diagnoses an abnormal form of Factor V, a variant of Factor V that forms a normal blood clotting process after an injury. When a mutation occurs, it blocks the clotting ability of Factor V. The irregularity and unregulated blood coagulation cause embolism and thrombosis in the body because of clot formation in the veins. 

Factor V Leiden is a common genetic mutation in the European population. The name ‘Leiden’ came after a name from a Dutch city. The factor V Leiden mutation test price depends on various factors, such as labs, location, and testing equipment. We at Redcliffe Labs offer a test price of 59% off, bringing the price from INR 14000 to INR 5900. We provide the shortest turnaround time (TAT) of 7 days. 

What is the Purpose of the Factor V Leiden Mutation Test? 

During the response to an injury, your body creates a clot with the support of two proteins: factor V and prothrombin. Hemostasis is a process that happens on the injured site to prevent bleeding. 

A coagulation cascade activates coagulation factors in sequence, eventually forming a blood clot. After healing, the clot resolves on its own. However, the number of coagulation factors and dissolving ability should be adequate. Any abnormality affects the working of blood clots, leading to excessive bleeding or clotting. 

A mutation in the Factor V Leiden can increase the risk of inappropriate blood clots. The factor V Leiden test can examine a person’s DNA, find chances of mutations or changes, and detect the risk of excessive blood clotting. 

What is the Factor V Leiden Mutation Test Used For? 

Doctors use Factor V Leiden to evaluate and diagnose inappropriate blood clot formation, including venous thromboembolism (VTE) and deep vein thrombosis (DVT). 

The test can also detect: 

• Whether you inherited a disorder connected with a blood clot 
• Whether you have one or two copies of mutations/changes (homozygous or heterozygous) 
• This is the reason for an initial damaging blood clot, which is especially common in people over 50 years old. 
• Whether people above 50 years of age have an unusual recurrence in the kidney, brain, liver, guts, or the eyes veins. 
• Whether VTE or venous thromboembolism reoccurs 
• Whether a person has a family history of thrombosis

Doctors might recommend the Factor V Leiden mutation test to detect the presence of Factor V mutation in family members. If they detect any presence, you are at a higher risk of developing a blood clot. However, exposure to genetic mutation varies among people. 

Symptoms Indicating The Need for Factor V Leiden Mutation Test 

Factor V Leiden mutation has no major symptoms. However, it can lead to abnormal blood clots in the lungs or legs. 

A person can experience certain symptoms of clots in the deep vein and lungs. 

• A clot in a deep vein 

Deep vein thrombosis (DVT) is a clot generally occurring in the legs, which may not cause any major symptoms. However, you may experience redness, inflammation, warmth, and pain. 

• A clot in the Lungs 

A lung clot occurs because of a pulmonary embolism when a DVT breaks down and travels to the lungs, affecting the blood flow. A person can experience certain life-threatening symptoms, such as: 

1. Rapid heartbeat 
2. Shortness of breath 
3. Chest pain while breathing in 
4. A bloody cough or blood-streaked sputum 

Why Can A Doctor Recommend The Factor V Leiden Mutation Test? 

A doctor can recommend the Factor V Leiden mutation test for detecting abnormalities in blood clotting. However, they can also suggest the test for several other purposes.

1. If you have blood clots in unusual parts like the kidneys, the brain, guts, pelvis, the liver, and the eye vein of the body. 
2. If you have a medical or family history of recurring deep vein thrombosis (DVT) or venous thromboembolism (VTE) 
3. If you experience your first DVT or VTE before age 50. 
4. If you had your first VTE because of oral contraceptives and pregnancy or hormone replacement therapy. 
5. If you experience any pregnancy complications such as miscarriages, especially during the second or third trimester. 
6. If the DVT or VTE reoccurs frequently. 

Centers for Disease Control and Prevention (CDC) conducted deep research on people to evaluate practical genomics and to decide on treatments, including anticoagulant medications. Out of all the people, some family members had the factor V Leiden or PT 20210 infection, while some were asymptomatic. 

Doctors recommend asymptomatic people take preventive measures, including limiting smoking and oral contraceptives and staying aware of the risk factors that might harm immobilization and surgery. 

Risk Associated with the Factor V Leiden Mutation Test 

Factor V Leiden mutation occurs because of a genetic mutation. However, studies show that people who have inherited factor V Leiden from one parent have a 5% chance of catching abnormal blood clots. However, certain factors can contribute to its risk. These include: 

1. Immobility 
2. Estrogens 
3. Two faulty genes 
4. Surgeries 
5. Injuries like broken bones 
6. non-O blood type 

Preparation for the Factor V Leiden Mutation Test 

The Factor V Leiden mutation test is an extemporaneous blood test. Experts recommend taking diagnostic tests from a reliable laboratory like Redcliffe Labs. We follow 50+ internal and external quality checks to ensure quality, and our DMLT-certified phlebotomists ensure a one-prick sample collection process. 

1. The test does not require fasting or dieting; however, diets differ for every individual. Consult a doctor to find out what suits you. 
2. Practicing deep-breathing exercises like yoga and meditation to prevent stress and anxiety. 
3. Clear all your queries and doubts with your doctor before the test. 
4. Avoid consuming harmful substances like alcohol and tobacco before the test. 
5. Don’t get up suddenly from the bed for sample collection. 
6. Avoid wearing full-sleeve clothes for sample collection. 

The Procedure of the Factor V Leiden Mutation Test 

For the Factor V Leiden mutation blood test, our phlebotomists follow a simple and smooth sample collection process. They collect the blood by inserting a sterile syringe into the vein and later transfer the collected blood into a container for analysis. They will also apply a cotton ball to the punctured site to prevent skin infection and blood loss. 

The procedure takes a couple of minutes and is eventually safe. Our phlebotomist transfers the blood to the lab for analysis, and you will receive the test reports within 7 days. 

Risks Associated with the Factor V Leiden Mutation Test 

The factor V Leiden mutation test has no risk. However, the process involves inserting a sterile syringe that may cause: 

• Excessive blood loss
• Slight pain 
• Hematoma 
• Weakness 
• Dizziness 
• Fatigue 
• Lightheadedness 
• Skin infection 

Understanding the Results of Factor V Leiden Mutation Test

The factor V Leiden mutation shows positive results when resistant to activated Protein C. However, doctors confirm the mutation through genetic testing. Factor V Leiden mutation is a common inherited genetic disorder that can be heterozygous or homozygous. 

Heterozygous is when you have one copy of the changed gene and one copy of the normal gene, while homozygous is when you have two copies of the changed gene, which is a rare condition. 

People with heterozygous have 5-10% higher chances of developing venous thromboembolism (VTE), and homozygous people are at high risk of thrombosis. 

Normal Range of Factor V Leiden Mutation Test 

The normal range of factor V Leiden mutation is 50% to 200% of the laboratory control. However, the range may differ from laboratory to laboratory. Other factors that can affect the factor V Leiden mutation test results include: 

• Age 
• Gender 
• Health history
• Medical history 
• Genetics 
• Inheritance 

What Other Additional Tests Can Your Doctor Suggest? 

The factor V Leiden mutation test is enough to determine the abnormalities forming a blood clot. Your doctor may recommend additional tests to help analyze the cause of thrombophilia or clotting disorders. These include: 

• Antithrombin 
• Homocysteine 
• Factor V gene R2 mutation 
• Protein C and Protein S 
• Lupus anticoagulant (LAC) 
• Factor V functional/ activity test 
• MTHFR mutation 

Redcliffe Labs offers a Thrombophilia profile with 10 parameters at 38%, bringing the test cost from INR 27700 to INR 17800. You can book the test from our website or mobile app, which will take a few minutes to complete. 

Treatment for the Factor V Leiden Mutation Test 

People with factor V Leiden mutation need no treatment. However, lifestyle modifications and certain blood thinners are effective treatments. 

Treatment lasts for three to six months. However, the type of anticoagulant may take longer than expected. Factors such as medications affect the treatment process. 

Other treatment processes include: 

1. Staying active 
2. Maintaining a healthy weight 
3. Quitting smoking and alcohol 
4. Avoiding injuries 
5. Being careful with estrogen 
6. Eating a healthy and low-sodium diet. 

With these simple lifestyle modifications and blood thinners, one can prevent the risk of blood clotting. 

Preventive measures for Blood Clotting 

There are ways through which you can prevent blood clotting. These preventive measures include: 

1. Drink enough fluids, mainly water. 
2. Avoid smoking and tobacco. 
3. Maintain a healthy weight. 
4. Prefer walking whenever you get time. 
5. Wear compression stockings. 
6. Practice brisk walking to prevent blood clots. 

Factor V Leiden Mutation Test Cost @ Redcliffe Labs 

Redcliffe Labs is an omnichannel diagnostic lab that provides quality diagnostics to every citizen. We offer over 3,600 tests in over 220+ cities with a home sample collection service. Our test range is affordable, making it accessible for all.

The factor V Leiden mutation test price is INR 5900, which helps detect the risk of venous thrombosis. The test price differs from lab to lab. With Redcliffe Labs, you can book the test and prevent the risk of blood clotting.

Factor V Leiden Mutation Test Price in Different Cities

Note: We also offer Factor V Leiden Mutation Test PAN India. Please call the number 8988988787 to check the availability of our services in your area.